Administration routes of prostaglandins:
By the mid 1980s prostaglandins had become established as the most effective pharmacological agents for inducing abortions and labor when the cervix is unripe.
A variety of administration routes had been employed during the preceding years, including oral, intravenous, sublingual, rectal, intra amniotic, extra amniotic, intra cervical, and vaginal administration.
The vaginal route is found to be the most acceptable, providing good efficacy and acceptability for the parturient and is now the preferred method of choice.
Types of prostaglandins commercially available:
Two forms of PGE2 are available commercially.
The first is Prostaglandin E2 (dinoprostone) formulated as gel and is placed inside the cervix but not above the internal os.
Prostaglandin E2 (dinoprostone) is licensed for the use of labour induction in the cases of viable pregnancies.
The application ( 3g gel / 0.5 mg dinoprostone) can be repeated in 6 hrs, not to exceed 3 doses in 24 hrs.
The second form is 10 mg of dinoprostone embedded in a mesh and is placed in the posterior fornix of vagina, this allows for control release of dinoprostone over 12 hrs, after which it is removed.
Prostaglandin E1 analog (misoprostol) available in tablet form for induction of labor was described recently in a series of articles.
This is a synthetic prostaglandin, which is marketed as an antinuclear agent under the trade name cytotec.
Generally 25 or 50 micro g placed in the posterior fornix, has been shown in several studies to be quite effective in inducing cervical ripening and initiation of abortion or labor.
The application of medication can be repeated every 4 -6 hrs up to 5 doses.
The major risk of above prostaglandin preparation is uterine polysystoly, hyper stimulation, meconium stained liquor and fetal distress.
The women and fetus must be monitored for contractions, fetal wellbeing and changes in Bishop score.
Prostaglandins-types
Prostaglandin-routes of administration
Prostaglandins- in inducing abortions
Prostaglandins-induction of labor
Cervidril, misoprostol
Prostaglandins- in PPH, uterine atony
By the mid 1980s prostaglandins had become established as the most effective pharmacological agents for inducing abortions and labor when the cervix is unripe.
A variety of administration routes had been employed during the preceding years, including oral, intravenous, sublingual, rectal, intra amniotic, extra amniotic, intra cervical, and vaginal administration.
The vaginal route is found to be the most acceptable, providing good efficacy and acceptability for the parturient and is now the preferred method of choice.
Types of prostaglandins commercially available:
Two forms of PGE2 are available commercially.
The first is Prostaglandin E2 (dinoprostone) formulated as gel and is placed inside the cervix but not above the internal os.
Prostaglandin E2 (dinoprostone) is licensed for the use of labour induction in the cases of viable pregnancies.
The application ( 3g gel / 0.5 mg dinoprostone) can be repeated in 6 hrs, not to exceed 3 doses in 24 hrs.
The second form is 10 mg of dinoprostone embedded in a mesh and is placed in the posterior fornix of vagina, this allows for control release of dinoprostone over 12 hrs, after which it is removed.
Prostaglandin E1 analog (misoprostol) available in tablet form for induction of labor was described recently in a series of articles.
This is a synthetic prostaglandin, which is marketed as an antinuclear agent under the trade name cytotec.
Generally 25 or 50 micro g placed in the posterior fornix, has been shown in several studies to be quite effective in inducing cervical ripening and initiation of abortion or labor.
The application of medication can be repeated every 4 -6 hrs up to 5 doses.
The major risk of above prostaglandin preparation is uterine polysystoly, hyper stimulation, meconium stained liquor and fetal distress.
The women and fetus must be monitored for contractions, fetal wellbeing and changes in Bishop score.
Prostaglandins-types
Prostaglandin-routes of administration
Prostaglandins- in inducing abortions
Prostaglandins-induction of labor
Cervidril, misoprostol
Prostaglandins- in PPH, uterine atony
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